The Immunological basis of Transfusion (HLS048)

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The Immunological basis of Transfusion (HLS048)

Module Objective

By the end of the training period, trainees will, in respect of Immunology, be able to:

  • analyse, synthesise, critically evaluate and apply knowledge
  • perform a range of clinical skills and procedures
  • demonstrate the attitudes and behaviours necessary for professional practice as a consultant clinical scientist dealing with the complexities, uncertainties and tensions of professional practice at this level

By the end of the training period the trainee will be able to demonstrate the ability to analyse, evaluate and synthesise relevant knowledge and its application to their professional practice in relation to:

  • principles of immunology, cellular and humoral immunity, innate and adaptive immunity
  • the structure and function of MHC, including the role of MHC molecules in the immune response
  • the structure and role of myeloid and lymphoid components of the immune system
  • the role of key accessory molecules including cytokines and cell adhesion molecules
  • the structure, function and production of immunoglobulins
  • the complement cascade
  • tolerance and loss of tolerance resulting in autoimmune conditions
  • the intravascular and extravascular destruction of red cells
  • the immunology of pregnancy
  • the pathogenesis of HDFN including placental transfer of IgG
  • the relationship between diagnostic assays used in blood transfusion and the pathogenesis of autoimmune and alloimmune haematological disorders including the immune destruction of red cells
  • the pathogenesis of:
    • HDFN
    • immunological reactions to blood transfusion
    • autoimmune disorders affecting red cells and platelets
  • the relationship between diagnostic assays used in blood transfusion and the pathogenesis of autoimmune and alloimmune haematological disorders including the immune destruction of red cells

By the end of the training period, with respect to Clinical and Laboratory Transfusion, trainees will be able to apply their expert knowledge of immunological theory to the performance of the clinical skills necessary to:

  • perform a range of clinical skills necessary to examine and interpret specimens in a systematic way.