Non-infectious Adverse Reactions to Red Cell Transfusion Therapy (HLS192)

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Non-infectious Adverse Reactions to Red Cell Transfusion Therapy (HLS192)

Module Objective

By the end of the training period with respect to non-infectious adverse reactions to red cell transfusion therapy, the trainee will be able to:

  • analyse, synthesise, critically evaluate and apply knowledge
  • perform, adapt and master a range of technical and clinical skills and procedures
  • demonstrate the attitudes and behaviours necessary for professional practice as a consultant clinical scientist dealing with the complexities, uncertainties and tensions of professional practice at this level

By the end of the training period the trainee will be able to demonstrate the ability to analyse, critically evaluate and synthesise relevant knowledge and its application to their professional practice in relation to:

  • the pathogenesis and presentation of immune-mediated transfusion reactions including:
    • Acute and delayed haemolytic
    • Febrile transfusion
  • the pathogenesis and presentation of non-immune-mediated transfusion reactions including
    • Volume overload
    • Hypotensive reaction
    • Citrate toxicity
    • Hyperkalemia
    • Hypothermia
    • Non-immune haemolysis (eg hypotonic solutions, pumps)
  • the investigation and diagnosis of the above disorders.
  • guidelines on the investigation and management of transfusion
  • anaphylactic and severe (anaphylactoid) reactions, including to IgA

By the end of the training period the trainee will be able to demonstrate a critical understanding of current relevant research, theory and knowledge and its application to the performance, adaptation and mastery of non-infectious adverse reactions to red cell transfusion therapy. Specifically the trainee will:

  • select, direct and interpret laboratory tests to support the diagnosis of adverse reactions to blood transfusion therapy

By the end of the training period the trainee will be able to apply their expert knowledge of adverse reactions to red cell transfusion therapy to perform, adapt and master the clinical skills necessary to:

  • provide expert advice on the selection of blood, blood products and components for patients who have reacted adversely to transfusion and on the contraindications of transfusion
  • provide expert advice on patients at risk of adverse reactions to blood products and on component selection and/or secondary processing to avoid haemolytic transfusion reactions, transfusion- associated graft versus host disease, and transfusion-associated circulatory overload