Immunity and the Principles and Practice of Histocompatibility and Immunogenetics (SLS101)

10 credits

Aim of this module

This module will enable trainees to apply their knowledge and understanding of the immune system and immune responses to (i) the services provided by Histocompatibility and Immunogenetics (H&I) laboratory services and (ii) the organisation and delivery of these services.

  1. Interpret routine requests for common H&I investigations in the correct clinical context and process the specimens that accompany those requests.
  2. Use laboratory IT systems for handling, processing, storing and retrieving patient data.
  3. Perform a range of laboratory techniques used in the workplace in H&I.
  4. Report the results of commonly performed H&I investigations.
  5. Apply the principles of internal quality control and external quality assessment and draw appropriate conclusions about assay performance.
Number Work-based learning outcome Title Knowledge
1 1,2

Identify the appropriate tests for at least two H&I clinical presentations.

2 1,2

Receive, label and store a range of immunological specimens

  • Serum specimens
  • DNA specimens
  • Lymphocyte specimens
3 3,5

Select and apply appropriate control materials.

4 3,5

Use automated methods, techniques and instrumentation to include at least four of the following:

  • Immunoassay
  • Electrophoresis
  • Immunoflourescence
  • Microscopy
  • Flow cytometry
  • X map technology
  • Complement dependent cytotoxicity
  • PCR
5 1,4,5

Interpret laboratory data in the light of clinical details on patients with common disorders where transplantation is the therapy of choice, including at least 2 of the following;

  • Autoimmune disorders
  • Immunodeficiency disorders
  • Renal disorders
  • Other solid organ disorders
  • Haematological malignancies
  • Disease associations
  • Drug hypersensitivity
6 1,2,4

Produce interpretative reports on laboratory investigations.

7 1,3

Control infection risks in accordance with departmental protocols.

8 1,3

Minimise risks and hazards in compliance with Health and Safety policies.

You must complete
1 Case-based discussion(s)
1 of the following DOPS / OCEs
Assessment Title Type
Receive label and store a selection of immunological specimens DOPS
Perform laboratory techniques used in clinical immunology DOPS
Demonstrate the ability to use laboratory IT systems for handling, processing and storage of patient data DOPS

Important information

The academic parts of this module will be detailed and communicated to you by your university. Please contact them if you have questions regarding this module and its assessments. The module titles in your MSc may not be exactly identical to the work-based modules shown in the e-portfolio. Your modules will be aligned, however, to ensure that your academic and work-based learning are complimentary.

Learning Outcomes

  1. Explain the function of the immune system in health and the function of the major cells of the immune system.
  2. Explain the function of the major humoral components of the immune response.
  3. Explain the innate immune system and the adaptive immune response.
  4. Discuss the co-dependence of the innate and adaptive immune systems.
  5. Describe and evaluate the design, operation and performance of the tests and assays used within clinical immunology.
  6. Describe the partnership of clinical immunology to other clinical specialisms in the investigation and management of disorders of the immune system and patient care. 

Indicative Content

  • Organisation and components of the immune system
    • Cellular components (lymphocytes, granulocytes, monocytes/macrophages)
    • Humoral components (antibodies/immunoglobulins, complement, cytokines)
    • Molecules of the immune system (major histocompatibility molecules class I and II, cluster of differentiation (CD) molecules/cell surface markers, receptor molecules, recognition molecules, adhesion molecules, effector molecules)
    • Antigen presentation
  • Innate immune response (endothelial cells, neutrophils, macrophages, natural killer cells, complement)
  • Adaptive immune response (antigen processing, dendritic cells, T cell responses, B cell responses, primary and secondary responses, vaccination/immunisation)
  • Outcome of immune responses (immunity/immunological memory, inflammation, direct and indirect functions of antibodies, incidental tissue damage, hypersensitivity and allergy)