Aim of this module
This module will provide the trainee with the knowledge and understanding of basic pharmacology and the mechanism of action of drugs. They will understand pharmacokinetics, pharmacogenomics and the criteria for valid therapeutic drug monitoring (TDM). They will optimise the use of commonly prescribed therapeutic drugs. They will be able to investigate the poisoned patient; screen for and confirm the presence of drugs of abuse. In the work-based module they will be expected to apply this knowledge as they learn to perform assays to assess therapeutic and toxic drugs using a range of methods and gain experience of the interpretation of results in a range of acute and chronic clinical conditions.
|Number||Work-based learning outcome||Title||Knowledge|
Perform the analyses to laboratory standard operating procedures for the following drugs:
Perform the analyses to laboratory standard operating procedures for drugs of abuse testing, including:
Perform the analyses to laboratory standard operating procedures for drugs/toxins commonly found in overdose:
Assist with two of the following analyses (following observation of a practitioner performing the relevant analysis):
Assist with at least one of the following pharmacogenetic assays (following observation of performance by practitioner):
Perform review of internal quality control (IQC) and external quality assessment (EQA) performance of a range of TDM and other drug assays.
Identify cases that require urgent intervention and offer clinical advice on the follow-up and/or further management of the patient.
Interpret biochemical and toxicological data in light of the clinical details.
Draft written reports on investigations.
|You must complete|
|2 Case-based discussion(s)|
|2 of the following DOPS / OCEs|
|Perform calibration and quality control of an automated analyser assay for a therapeutic drug||DOPS|
|Perform screening tests for drugs of abuse||DOPS|
|Refer drugs of abuse samples which test positive for confirmatory testing||DOPS|
|Perform confirmatory testing for drugs of abuse samples||DOPS|
|Select the sample type and preanalytical requirements and undertake the measurement of digoxin||DOPS|
|Select the sample type and preanalytical requirements and undertake the measurement of an immunosuppressives drug||DOPS|
|Select the sample type and preanalytical requirements and undertake the measurement of an antibiotic.||DOPS|
|Identify refer and report toxicology samples which require urgent analysis at an external laboratory||DOPS|
|Interpret an External Quality Assurance Report for an anticonvulsant||DOPS|
|Interpret an External Quality Assurance Report for an immunosuppressant drug||DOPS|
|Interpret an External Quality Assurance Report for an antibiotic||DOPS|
|Perform a paracetamol assay||DOPS|
|Perform an ethanol assay||DOPS|
|Discuss an abnormal paracetamol result and the therapeutic intervention with a healthcare professional||OCE|
The academic parts of this module will be detailed and communicated to you by your university. Please contact them if you have questions regarding this module and its assessments. The module titles in your MSc may not be exactly identical to the work-based modules shown in the e-portfolio. Your modules will be aligned, however, to ensure that your academic and work-based learning are complimentary.