Haematopoietic Stem Cell Transplantation (SLS129)

10 credits

Aim of this module

This module will provide the trainee with a knowledge and understanding of stem cell donation, testing, harvesting and monitoring. They will understand a range of clinical conditions associated with stem cell transplantation requirements. They will gain experience of HLA typing in the matching of donors and suitable recipients. In the work-based module they will be expected to apply this knowledge as they learn to perform relevant laboratory methods and gain experience of the interpretation of patient results in a variety of clinical settings.

This module will provide the trainee with the practical application of knowledge and skills relating to Histocompatibility and Immunogenetics techniques applicable to haematopoietic stem cell transplantation.

 

  1. Perform the clinical and laboratory investigation of patients being considered for HSCT including the interpretation and reporting of results in the correct clinical context.
  2. Select suitable donors for HSCT under supervision.
  3. Assess the suitability of potential related and unrelated (adult and cord blood) donors for HSCT.
  4. Perform clinical and laboratory monitoring of patients who have received haematopoietic stem cell transplantation.
  5. Work in partnership with other clinical specialisms in the investigation of haematopoietic stem cell transplantation and, where appropriate, with service users and support staff.
Number Work-based learning outcome Title Knowledge
1 1

Analyse family HLA results to produce pedigree data.

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2 1,2

Review and select potential related  donors for HSCT, using local and national protocols.

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3 1,2

Review and select potential unrelated adult donors for HSCT, using local and national protocols.

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4 1,2

Review and select potential cord donors for HSCT, using local and national protocols.

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5 1,2,3,5

Assess the suitability of potential related and unrelated (adult and cord blood) donors for HSCT, using local and national protocols

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6 1,2,3,5

Produce an interpretive report of the suitability of potential related and unrelated (adult and cord blood) donors for HSCT for clinical colleagues.

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7 1,4

Perform chimerism analysis to assess and monitor patients post HSCT.

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8 1,4,5

Produce an interpretive chimerism report for clinical colleagues, using local and national protocols.

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9 5

Work in partnership with other clinical specialisms in the investigation of haematopoietic stem cell transplantation and, where appropriate with service users and support staff.

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10 5

Communicate effectively with the healthcare team recognising and responding appropriately to situations where it is necessary to share information to safeguard service users or the wider public.

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You must complete
2 Case-based discussion(s)
2 of the following DOPS / OCEs
Assessment Title Type
Prepare an interpretive family pedigree report DOPS
Conduct a search for an unrelated stem cell donor DOPS
Conduct a search for an unrelated cord blood donor DOPS
Prepare an interpretive report of the suitability of potential related and unrelated donors DOPS
Perform tests to monitor post- transplant engraftment DOPS
Prepare an interpretive report for chimerism monitoring DOPS
Attend ward rounds and/or clinics at which patients are being worked up for, or monitored following haematopoietic stem cell transplantation and describe to the patient the involvement of the Laboratory in their care OCE
Attend a multidisciplinary review meeting at which laboratory results are presented and describe to colleagues what they mean. OCE
Take a patient history OCE

Important information

The academic parts of this module will be detailed and communicated to you by your university. Please contact them if you have questions regarding this module and its assessments. The module titles in your MSc may not be exactly identical to the work-based modules shown in the e-portfolio. Your modules will be aligned, however, to ensure that your academic and work-based learning are complimentary.

Learning Outcomes

  1. Explain the role of HSCT in the treatment of various haematopoietic disorders.
  2. Know the nomenclature of the HLA system and discuss its role in the selection of donors for HSCT.
  3. Describe the design, operation and performance of HLA typing methods for HSCT according to current guidelines.
  4. Explain the principles of post-transplant monitoring and its role in patient management.
  5. Describe the partnership between histocompatibility and immunogenetics and other clinical specialisms in the investigation of HSCT and patient care.

Indicative Content

  • Principles of HSCT
  • HLA genetics and nomenclature
  • Stem cell sources
  • Principles of donor selection
  • Pre-transplant work-up
  • Compatibility testing
  • Stem cell registries – Bone Marrow Donors Worldwide (BMDW), Anthony Nolan Trust (ANT), Worldwide Network for Blood and Marrow Transplantation (NetCord)
  • Principles of post-transplant monitoring
  • Graft versus host disease and graft versus leukaemia
  • Legislation: Joint Accreditation Committee – ISCT & EBMT (JACIE), Human Tissue Authority (HTA), European Federation for Immunogenetics (EFI), Foundation for the Accreditation of Cellular Therapy (FACT)