Hematological Malignancy (SLS131)

10 credits

Aim of this module

This module will provide the trainee with knowledge and understanding of the pathophysiology, clinical presentation and management of patients with haematological malignancy. In the work-based module they will be expected to apply this knowledge as they learn to perform relevant laboratory methods and gain experience of the interpretation of patient results in a variety of clinical settings.

  1. Perform a range of laboratory and molecular testing techniques used in the workplace to diagnose and monitor treatment of haematological malignancy.
  2. Perform laboratory investigations and outline the management of haematological malignancy in the correct clinical context, including the interpretation and reporting of results.
  3. Interpret and comply with national and international guidance (e.g. NICE, WHO, BCSH) on the diagnosis and management of haematological cancer.
Number Work-based learning outcome Title Knowledge
1 1

Perform a range of methods for diagnosing and monitoring treatment of haematological malignancy, including:

  • morphology screening
  • immunophenotyping by flow cytometry
  • karyotyping
  • fluorescence in-situ hybridisation panels
  • molecular diagnostics, including:
  • IgH gene rearrangement
  • TCR gene rearrangement
  • BCRABL
  • JAK2
  • FLT3/NPMI
  • minimal residual disease monitoring
  • post-transplant chimera monitoring.
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2 2

Interpret haematology data in order to aid the classification of haematological malignancies.

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3 2

Interpret laboratory data in light of clinical details and authorise written reports under supervision on patients with lymphoid cell disorders, including:

  • acute lymphoblastic leukaemia
  • chronic lymphocytic leukaemia
  • Hodgkin’s lymphomas
  • non-Hodgkin’s lymphomas
  • acute myeloid leukaemia
  • chronic myeloid leukaemia
  • myelomas.
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4 3

Interpret laboratory data in patients for whom haemopoietic stem cell transplantation is the appropriate treatment.

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5 3

Interpret and comply with appropriate national and international guidelines for the diagnosis and management of haematological malignancies.

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You must complete
2 Case-based discussion(s)
2 of the following DOPS / OCEs
Assessment Title Type
Demonstrate practical understanding of the principles of flow cytometry DOPS
Review bone marrow films DOPS
Describe the WHO classification system and other relevant systems guidelines DOPS
Perform storage and processing of stem cells prior to transplantation DOPS
Attend an outpatient clinic and take a case history from a recipient and donor OCE
Attend an outpatient clinic and take a case history from a recipient and donor medium OCE
Attend a haematology oncology ward round and take a patient history OCE
Interpret data and prepare case study to illustrate how laboratory results link to clinical outcomes and explain the results to clinical colleagues DOPS
Interpret data and present case at an MDT meeting DOPS

Important information

The academic parts of this module will be detailed and communicated to you by your university. Please contact them if you have questions regarding this module and its assessments. The module titles in your MSc may not be exactly identical to the work-based modules shown in the e-portfolio. Your modules will be aligned, however, to ensure that your academic and work-based learning are complimentary.

Learning Outcomes

  1. Explain the classification, aetiology and genetics of haematological malignancy.
  2. Describe the design, operation and performance of laboratory and molecular techniques used in the investigation and management of haematological malignancy.
  3. Discuss the principles of bone marrow and stem cell harvests and their role in transplantation programmes.
  4. Discuss the principles and mechanisms of chemotherapy, immunotherapy and radiotherapy and their use in haematological malignancy.
  5. Describe and justify the importance and implementation of national (e.g. NICE) guidance on the diagnosis and management of haematological cancer.
  6. Describe and justify the importance of integrated diagnosis of haematological malignancy.
  7. Describe the partnership between the haematology laboratory and other clinical specialisms in the investigation of haematological malignancy and patient care.

Indicative Content

Current concepts on the aetiology, pathogenesis and molecular mechanisms involved in

  • Myeloid malignancy
  • Lymphoid leukaemia
  • Lymphoma
  • Myeloma and plasma cell disorders
  • Myelodysplastic syndromes
  • Diagnosis and management of the above
  • Myeloproliferative disorders and their diagnosis and management
  • Bone marrow failure syndromes
  • Blood and bone marrow transplantation regimes
  • Principles of chemo- and radiotherapy and the rationale behind Medical Research Council (MRC) acute myeloid leukaemia (AML) and acute lymphoblastic leukaemia (ALL) trials
  • Survival rates in haematological malignancy
  • IQC and EQA in haemato-oncology
  • BCSH guidelines in haemato-oncology; NICE improved outcome guidance