Aim of this module
This module will provide the trainee with knowledge and understanding of the causes of immunodeficiency. They will understand the clinical presentation and investigation of a range of immunodeficient conditions and the principles and practice of immunotherapy. They will become familiar with methods and strategies to investigate immunodeficiency and gain experience of the interpretation of patient results in a variety of clinical settings.
|Number||Work-based learning outcome||Title||Knowledge|
Select the appropriate immunological assay to investigate whether the immune system of the patient is immunocompetent or immunodeficient. To include all of the following:
Perform the appropriate investigation of immunodeficiency to include all specified. To include all of the following:
Interpret immunological data in the light of clinical details on patients with primary immunodeficiency, including:
Interpret immunological data in light of clinical details on patients with secondary immunodeficiency, including all of the following:
Interpret immunological data in light of clinical details.
Apply the appropriate immunotherapeutic strategies/treatment regimens for patients with a range of primary and secondary immunodeficiencies.
Interpret, assess the effectiveness of and report results from patients receiving a range of immunotherapies, including at least three of the following:
Identify relevant clinical investigations from other disciplines that will impact on the interpretation of the immunological investigation.
|You must complete|
|2 Case-based discussion(s)|
|2 of the following DOPS / OCEs|
|Perform analysis of a patients serum to determine levels of immunoglobulins IgG IgM IgA||DOPS|
|Perform the flow cytometric assay to determine the number of CD4 T cells||DOPS|
|Perform the assay to determine the level of anti tetanus Or anti pneumococcus Or anti Hib IgG antibodies in a patient serum sample||DOPS|
|Perform the assay to determine the C3 and C4 levels in a patient sample||DOPS|
|Perform a lymphocyte proliferation assay||DOPS|
|Perform a neutrophil functional assay||DOPS|
|Perform the C100 or C50 assay to see if the classical pathway of complement is working in a patient||DOPS|
|Perform the AP50 AP100 assay to see if the alternative pathway of complement is working in a patient||DOPS|
|Perform TCR V beta analysis||DOPS|
|Take a history where the patient is suspected of having an immunodeficiency disorder||OCE|
|Describe to a patient with CVID XLA other antibody deficiency why you need to take EDTA blood to examine the B and T cells or measure immunoglboulins||OCE|
|Observe and then report to the clinician on taking blood for immunoglobulin measurement or for B and T cells from a patient||OCE|
|Discuss with a patient undergoing intravenous subcutaneous immunoglobulin therapy about this treatment and how it is helping them||OCE|
|Attend an MDT meeting of clinical immunologists and present the results of patient testing||OCE|
|Attend an outpatient clinic within any discipline gastro rheumatology dermatology renal etc where the patient may have an immunological dysfunction as part of their disease||OCE|
|Obtain a patient history from a normal volunteer or typical patient referred to your service and present the findings to a colleague or peer||OCE|
The academic parts of this module will be detailed and communicated to you by your university. Please contact them if you have questions regarding this module and its assessments. The module titles in your MSc may not be exactly identical to the work-based modules shown in the e-portfolio. Your modules will be aligned, however, to ensure that your academic and work-based learning are complimentary.