Infertility, Treatment and Role of Regulation (SLS327)

10 credits

Aim of this module

This module will provide the trainee with knowledge and understanding of the causes and treatment options for male and female infertility and the approach to managing the infertile couple. They will understand the role of regulation in treating infertility and become familiar with legislatory quality management aspects of licensed treatments.

  1. Suggest a patient’s pathway, including treatment options and stimulation regimens based on clinical presentation.
  2. Perform procedures within the statutory and regulatory framework.
  3. Perform quality management tasks.
Number Work-based learning outcome Title Knowledge
1 1

Review case notes to link the cause of infertility with the suggested treatment plan and produce an interpretive report of the investigations.

2 1

Plan and optimally time a thaw/warming cycle within a natural or hormone replacement therapy (HRT) cycle.

3 2

Perform witness checks during a procedure to meet Human Fertilisation and Embryology Authority (HFEA) requirements.

4 2

Review the required consents appropriate for a variety of treatment cycles, including those involving donated gametes.

5 3

Perform quality assurance and quality control tasks within the laboratory.

6 3

Perform and report a risk assessment for one procedure performed in your laboratory.

7 2,3

Follow the appropriate guidelines for incident reporting within the centre.

8 2

Minimise risks and hazards in compliance with health and safety policies.

You must complete
2 Case-based discussion(s)
2 of the following DOPS / OCEs
Assessment Title Type
Peform an EQR DOPS
Undertake a NEQAS submission for both sperm and embryos DOPS
Perform QC checks on a specific piece of equipment DOPS
Examine consents in the patients notes for appropriateness and accuracy for the selected treatment DOPS
Perform an audit DOPS
Perform a risk assessment DOPS
Complete an incident report form through your internal system DOPS
Perform a health and safety audit DOPS
Perform a witnessing audit DOPS
Perform a COSHH assessment DOPS
Review a patient notes to plan when embryos should be thawed rewarmed within the frozen embryo replacement cycle, discuss and confirm the thaw plan with the patient. OCE

Important information

The academic parts of this module will be detailed and communicated to you by your university. Please contact them if you have questions regarding this module and its assessments. The module titles in your MSc may not be exactly identical to the work-based modules shown in the e-portfolio. Your modules will be aligned, however, to ensure that your academic and work-based learning are complimentary.

Learning Outcomes

  1. Discuss the causes and diagnosis of male and female infertility.
  2. Discuss and justify the treatment options for male and female infertility.
  3. Describe different ovarian stimulation regimens, including the endocrine and physiological responses.
  4. Explain and critically evaluate the statutory and regulatory requirements of fertility treatments and professional codes of practice.
  5. Explain and evaluate the principles and practice of quality management and validation.
  6. Discuss the linkages between the reproductive science laboratory and other clinical specialisms in the investigation of male and female infertility and patient care.

Indicative Content

  • Investigation of the infertile male, including specialist andrology testing
  • Causes of male infertility, including endocrine deficiencies, obstructions, genetic and chromosomal disorders, autoimmunity, varicocele
  • Treatment options for male infertility
  • Investigation of the infertile female
  • Causes of female infertility, including endocrine disorders, genetic and chromosomal disorders, tubal disorders, endometriosis
  • Treatment options for female infertility
  • In-vivo oocyte development and ovarian stimulation regimens, including mechanism of actions of antagonists and agonists
  • Endocrine and physiological response to ovarian stimulation
  • Luteal endocrinology
  • Outcomes of ART treatment
  • The Human Fertilisation and Embryology Act and Code of Practice
  • Legislation and regulatory mechanisms in the UK compared with those both within and outside the EU
  • Governing bodies and accrediting organisations
  • Licensing for both treatment and research in the UK
  • Social and ethical responsibilities of a clinical embryologist
  • Quality control tests routinely employed in the ART lab – mouse embryo bioassay and sperm survival tests
  • Quality management system within an (in-vitro fertilisation) IVF centre
  • Validation of equipment and processes