Major Organ Histopathology excluding Cancer (SLS329)

10 credits

Aim of this module

This module will provide the trainee with knowledge and understanding of the cellular structure and function of the major organs and the cellular pathological findings in a range of clinical disorders other than cancer. They will understand and apply a range of techniques to these clinical disorders and gain experience of interpreting results from patient investigations.

  1. Identify and confirm clinical presentation of a range of major organ diseases.
  2. Perform to quality standards a range of established histopathological techniques to named disorders of the major organs.
  3. Identify and evaluate new equipment, methods, or procedures to enhance the contribution of the histopathology laboratory to the diagnosis and management of major organ disease.
  4. Under supervision, prepare and interpret reports that involve histopathological findings as part of the investigation of major organ disease.
  5. Work in partnership with other clinical specialisms as part of the diagnosis and review of named clinical diseases of major organs.
Number Work-based learning outcome Title Knowledge
1 1

From routine requests, identify the histopathological specimens required to confirm a diagnosis in each major organ system and perform the relevant techniques to process the sample.

Essential

  • Dermatopathology
  • Breast pathology
  • Hepatobiliary pathology
  • Gastrointestinal pathology
  • Genitourinary pathology
  • Respiratory pathology
  • Gynaecological pathology
  • Male reproductive pathology
  • Endocrine pathology

 

Desirable

  • Ear, nose and throat pathology
  • Osteoarticular pathology
  • Cardiac and vascular pathology
  • Neuropathology.
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2 2

Perform and record details of macroscopic examination of tissue received from named major organ disease. To include:

Essential

  • Dermatopathology
  • Breast pathology
  • Hepatobiliary pathology
  • Gastrointestinal pathology
  • Genitourinary pathology
  • Respiratory pathology
  • Gynaecological pathology
  • Male reproductive pathology
  • Endocrine

 

Desirable

  • Ear, nose and throat pathology
  • Osteoarticular pathology
  • Cardiac and vascular pathology
  • Neuropathology.
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3 2

Perform to quality standards, basic and appropriate specialised histopathological techniques as part of the systematic investigation of tissue received from named major organ disease. To include:

Essential

  • Dermatopathology
  • Breast pathology
  • Hepatobiliary pathology
  • Gastrointestinal pathology
  • Genitourinary pathology
  • Respiratory pathology
  • Gynaecological pathology
  • Male reproductive pathology
  • Endocrine pathology

 Desirable

  • Ear, nose and throat pathology
  • Osteoarticular pathology
  • Cardiac and vascular pathology
  • Neuropathology.
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4 3

Perform a detailed evaluation of one new piece of equipment, method or procedure.

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5 1,2,3

Perform to quality standards histopathological tests of rejection from tissue grafts and/or organ transplantation.

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6 4

In discussion with a pathologist interpret in the correct clinical context the results of:

  • macroscopic examination
  • basic microscopic examination
  • appropriate specialised techniques
  • diagnostic algorithims

from specimens received from a range of named major organ diseases, to include:

  • dermatopathology
  • breast pathology
  • hepatobiliary pathology
  • gastrointestinal pathology
  • genitourinary pathology
  • cardiac and vascular pathology
  • respiratory pathology
  • gynaecological pathology
  • male reproductive pathology
  • endocrine pathology
  • ear, nose and throat pathology
  • osteoarticular pathology.
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7 4

In discussion with a pathologist, prepare and issue reports from the selected cases of named major organ disease in the context of other clinical information.

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You must complete
2 Case-based discussion(s)
2 of the following DOPS / OCEs
Assessment Title Type
Perform interpretation of clinical details from 10 examples of major organ resections and prioritise samples according to clinical urgency. DOPS
Perform interpretation of clinical details from 10 examples of major organ resections and plan the investigations to be performed and annotate the request accordingly. DOPS
Perform specimen dissection of a range of major organ resection sample types requiring dissection with a knife DOPS
Perform assessment and marking of relevant specimen excision margins. DOPS
Perform dictated description of 10 specimens being dissected, detailing all required descriptors according to local protocols. DOPS
Perform microtomy on 10 different tissue types from different major organ resections and stain with H and E stain, DOPS
Perform microscopical interpretation of stained slides and produce a quality assessment evaluation report DOPS
From evidence gathered and discussions with relevant clinical colleagues, produce a clinical pathway document detailing the impact of the diagnostic process on the overall patient pathway. OCE
From evidence gathered and discussions with relevant clinical colleagues, produce a reflective account of the learning acquired OCE
Perform microscopical interpretation of H and E stained slides from 6 different major organ types and demonstrate to a Consultant Histopathologist normal and abnormal morphology, relating their morphologic appearance to the clinical condition. OCE
Perform microscopical interpretation of stained slides from 6 different major organ types and demonstrate to a Consultant Histopathologist the algorithmic processes used to determine a differential diagnosis. OCE
In discussion with a Consultant Histopathologist, use information gathered from the algorithmic process to produce a preliminary diagnosis for 6 specimens from different major organ types. OCE
From evidence gathered, discuss differential diagnosis at a relevant MDT meeting. OCE

Important information

The academic parts of this module will be detailed and communicated to you by your university. Please contact them if you have questions regarding this module and its assessments. The module titles in your MSc may not be exactly identical to the work-based modules shown in the e-portfolio. Your modules will be aligned, however, to ensure that your academic and work-based learning are complimentary.

Learning Outcomes

  1. Describe the structure and function of the major organ groups in the human body and their interactions with each other.
  2. Explain the pathophysiology and clinical presentation of common disorders of major organs.
  3. Describe systemic and local disease within major organ systems.
  4. Describe the application of established histopathological techniques to a range of named disorders of the major organs.
  5. Discuss the principles and practice of major organ transplantation, including immunosuppression.
  6. Discuss and critically evaluate the ethical and legislative processes associated with the investigation of major organ disease.
  7. Discuss the role of the histopathology report as part of the decision-making process in guiding diagnosis, management and clinical outcomes in major organ disease.

Indicative Content

  • Aetiology, pathogenesis and main clinical features of common diseases encountered in cellular pathology and their impact on patient management, including:
    • dermatopathology, e.g. non malignant skin lesions
    • breast pathology, e.g. adenomas, fibrocystic change
    • hepatobilary pathology, e.g. cirrhosis, cholecystitis
    • gastrointestinal pathology, e.g. diverticulitis, polyposis, inflammatory bowel disease
    • genitourinary pathology, e.g. prostatic hyperplasia, pyelonephritis, urothelial papillary lesions
    • cardiac and vascular pathology, e.g. ischaemic heart disease
    • respiratory pathology, e.g. chronic obstructive pulmonary disease (COPD), fibrosis
    • gynaecological pathology, e.g. endometriosis, fibrous diseases
    • male reproductive pathology, e.g. epididymal cysts
    • endocrine pathology, e.g. goitre
    • ear, nose and throat (ENT) pathology, e.g. nasal polyps, tonsillitis, cystic lesions
    • osteoarticular pathology, e.g. osteoarthritis and rheumatoid arthritis
  • Application of a wide range of histological techniques to the demonstration of the disease processes, e.g. diagnostic algorithms
  • Awareness of the multi-organ impact of disease and treatment
  • Organ transplantation and the morphological presentation of rejection
  • Multi-organ transplant
  • Ethical and regulatory issues
  • New developments in equipment, methods or procedures used in the laboratory investigation of major organ disease
  • The importance of the histopathology report in assisting diagnosis, management and clinical outcomes