Specialised Histopathology (SLS336)

10 credits

Aim of this module

This module will provide the trainee with knowledge and understanding of application of histopathology to specialised clinical situations, including autopsy. They will apply this knowledge as they use cellular pathology techniques in specialised situations and gain experience of interpreting results from patient investigations.

  1. Identify the clinical presentation of a range of relevant disorders of specialised organ groups and clinical subspecialist areas.
  2. Perform to quality standards a range of specialised histopathology techniques.
  3. Identify and evaluate new equipment, methods, or procedures to enhance the contribution of the histopathology laboratory to the diagnosis and management of specialised organ groups and clinical subspecialist areas.
  4. Support the organisation and use of specialised histopathology laboratory services in the UK.
  5. Under supervision, prepare and interpret histopathology reports that involve specialised organ groups and clinical subspecialist areas.
  6. Support mortuary operation, the autopsy process and the associated regulatory framework. Where appropriate, observe autopsy in action.
  7. Work in partnership with other clinical specialisms as part of the diagnosis and review of patients with disorders of specialised organ groups and from clinical subspecialist areas.
Number Work-based learning outcome Title Knowledge
1 1

From routine requests, identify the histopathological specimens required to confirm a diagnosis for:

  • ophthalmic pathology
  • neuromuscular pathology
  • central nervous system pathology
  • haemopoietic pathology.
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2 2

Perform and record details of macroscopic examination of tissue received from named diseases of:

  • ophthalmic pathology
  • neuromuscular pathology
  • central nervous system pathology
  • haemopoietic pathology.
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3 2

Dissect and sample specimens received in accordance with local protocols.

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4 2

Perform to quality standards basic and appropriate specialised histopathological techniques as part of the systematic investigation of tissue received from named diseases of:

  • ophthalmic pathology
  • neuromuscular pathology
  • central nervous system pathology
  • haemopoietic pathology.
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5 3

Identify and describe relevant new equipment, methods or procedures that may be able to enhance the contribution of the histopathology laboratory specialised areas of medicine.

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6 4

Report on the UK centres undertaking specialised histopathology investigations, giving examples from your own experience of the specialised tests provided in named disorders.

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7 5,7

In discussion with a pathologist interpret in the correct clinical context the results of:

  • macroscopic examination
  • basic microscopic examination
  • appropriate specialised techniques
  • diagnostic algorithms

from specimens received from a range of named specialist systems, to include:

  • ophthalmic pathology
  • neuromuscular pathology
  • central nervous system pathology
  • haemopoietic pathology.
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8 6

Identify and apply the relevant legislation and guidance that applies to the autopsy and the retrieval of tissue.

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You must complete
2 Case-based discussion(s)
2 of the following DOPS / OCEs
Assessment Title Type
Perform interpretation of clinical details from 10 examples of specialised organ or tissue resections and prioritise samples according to clinical urgency. DOPS
Perform interpretation of clinical details from 10 examples of specialised organ or tissue resections and plan the investigations to be performed and annotate the request accordingly. DOPS
Perform specimen dissection of a range of specialised organ or tissue resection sample types requiring dissection with a knife and select appropriate samples to enable a diagnosis to be made. DOPS
Perform assessment and marking of relevant specimen excision margins to enable correct orientation of the samples. DOPS
Perform dictated description of 10 specialised organ or tissue resection specimens being dissected, detailing all required descriptors. DOPS
Perform microtomy on 10 different tissue types from different specialised organ or tissue resections and stain with H and E stain. DOPS
Evaluate and perform a prognostic indicator assessment using the appropriate demonstration technique to a named disease type. DOPS
Perform microscopical interpretation of stained slides and produce a quality assessment evaluation report. DOPS
From evidence gathered and discussions with relevant clinical colleagues, produce a clinical pathway document detailing the impact of the diagnostic process on the overall patient pathway. OCE
From evidence gathered and discussions with relevant clinical colleagues, produce a reflective account of the learning acquired OCE
Perform microscopical interpretation of H and E stained slides from 6 different specialised organ or tissue types and demonstrate to a Consultant Histopathologist normal and abnormal morphology, relating their morphologic appearance to the clinical condition. OCE
Perform microscopical interpretation of stained slides from 6 different specialised organ or tissue types and demonstrate to a Consultant Histopathologist the algorithmic processes used to determine a differential diagnosis. OCE
In discussion with a Consultant Histopathologist, use information gathered from the algorithmic process to produce a preliminary diagnosis for 6 specimens from different specialised organ or tissue types. OCE
From evidence gathered, discuss differential diagnosis at a relevant MDT meeting. OCE

Important information

The academic parts of this module will be detailed and communicated to you by your university. Please contact them if you have questions regarding this module and its assessments. The module titles in your MSc may not be exactly identical to the work-based modules shown in the e-portfolio. Your modules will be aligned, however, to ensure that your academic and work-based learning are complimentary.

Learning Outcomes

  1. Describe the structure and function of specialised organ groups in the human body and their interactions with each other.
  2. Discuss and evaluate the application of histopathology in clinical sub- specialist areas, including paediatrics.
  3. Discuss and evaluate the application of specialised histopathology equipment and techniques in a variety of clinical settings.
  4. Discuss the contribution of the histopathology report to the diagnosis and further management of specialised organ groups and clinical sub-specialist areas.
  5. Explain and evaluate the organisation and delivery of specialised histopathology services and the procedures required for use of those services.
  6. Discuss the autopsy process and the associated regulatory framework.
  7. Discuss the partnership of histopathology to other clinical specialisms in the investigation and management of cancer and patient care.

Indicative Content

  • Aetiology, pathogenesis and main clinical features of common diseases encountered in cellular pathology and their impact on patient management, including:
    • haemopoietic pathology, e.g. hyperplasia, lymphadenitis
    • neuromuscular pathology, e.g. neuroma, schwannoma, myology
    • central nervous system (CNS) pathology
    • ophthalmic pathology, e.g. trachoma
    • eye
    • brain
    • muscle
    • nerve
    • paediatric pathology
    • haematopathology
  • Application of specialised techniques to a variety of tissues:
    • specialised immunocytochemistry
    • immunofluorescence
    • fluorescence in-situ hybridisation
    • molecular techniques, e.g. PCR
    • electron microscopy
    • image capture
    • quantitation
    • molecular databases
  • Specialised techniques currently under development that may play a future role in cellular pathology
  • Knowledge of autopsies and the underlying principle of consent:
    • perinatal and paediatric post mortems
    • coroner’s post mortems
    • forensic post mortems
  • Human Tissue Authority (HTA) regulations relating to the retention of tissues and organs
  • Tissue banking