Aim of this module
This module will provide trainees with the knowledge and understanding of the different reasons males seek fertility preservation, the principles and practice of cryopreservation and associated regulatory requirements.This module will consider the techniques of sperm processing and cryopreservation critically evaluating the principles, practices and risks alongside the evidence base to optimise the chance of having healthy offspring. The trainee will explore ethical and safety issues including patient, partners and family perspectives and what is required of a clinical scientist by the Health and Care Professions Council. They will understand and gain experience in sperm preparation and insemination methodologies. The trainees will also learn how to report results from freezing and thawing. Trainees should gain insight into patient perspectives and information sharing with patients and how well this is understood.
|Number||Work-based learning outcome||Title||Knowledge|
Obtain consent from a range of patients referred to Andrology Services.
Maintain and select culture systems.
Perform and interpret swim-up techniques and density gradient separation of sperm samples of different quality, including:
Label and perform witnessing prior to cryopreservation and following thawing/warming of semen.
Perform sperm cryopreservation Correctly use and handle liquid nitrogen and associated cryogenic equipment.
Thaw semen samples and compare pre-freeze and post-thaw parameters.
Release and receive cryopreserved gametes and embryos to other centres.
Fill and label a nitrogen shipping container.
Work safely in the laboratory to reduce the risk of transmission of infections, e.g. blood-borne viruses.
|You must complete|
|2 Case-based discussion(s)|
|2 of the following DOPS / OCEs|
|Prepare sperm from semen in compliance with relevant local practice by gradient and swim-up methods||DOPS|
|Culture prepared sperm and control media for 24h to assess aseptic preparation technique||DOPS|
|Perform QC checks within a cryofacility||DOPS|
|Perform slow freezing of sperm samples and review how method optimization may improve survival / sperm quality.||DOPS|
|Correctly complete HFEA consents for sperm storage and use with a patient||DOPS|
|Provide results of a sperm banking event to a patient / donor.||DOPS|
|Review a number of sets of case notes and recommend patient pathways including treatment options based upon these.||OCE|
|Present to the laboratory team a summary of the dangers of liquid nitrogen use and how to mitigate these.||OCE|
|Evaluate the potential effects on a potential sperm donor / banking patient of unexpected findings about their fertility, particularly with regard to azoospermia. Discuss with your team how these relate to best practice locally.||OCE|
The academic parts of this module will be detailed and communicated to you by your university. Please contact them if you have questions regarding this module and its assessments. The module titles in your MSc may not be exactly identical to the work-based modules shown in the e-portfolio. Your modules will be aligned, however, to ensure that your academic and work-based learning are complimentary.