Aim of this module
This module will provide the trainee with knowledge and understanding of the role and application of genetic and genomic testing in the diagnosis and management of patients with sporadic cancers.
The content for this module will focus on (as exemplars) patients who present with acquired cancers including Chronic Myeloid Leukaemia (CML), Acute Lymphoblastic Leukaemia (ALL), Acute Myeloid Leukaemia (AML), sporadic colorectal cancer and lung cancer.
|Number||Work-based learning outcome||Title||Knowledge|
Select the correct genetics test for patients referred with acquired cancer.
Perform gene fusion analysis using appropriate current technology on oncology samples.
Perform whole genome analysis on samples from patients with leukaemia at diagnosis.
Perform appropriate molecular testing on various cancer samples.
Perform appropriate genetic testing for monitoring and measurement of disease in relation to both treatment and prognosis.
Interpret and report on a range of genetic testing in haematological malignancy, including both diagnostic and follow-up (monitoring) analysis.
|You must complete|
|2 Case-based discussion(s)|
|2 of the following DOPS / OCEs|
|Perform duty scientist checking of samples referred for acquired cancer||DOPS|
|Analyse chromosomes from a routine haematological malignancy||DOPS|
|Interpret the results of analysis to monitor Minimal Residual Disease||DOPS|
|Analyse the results of RQ PCR analysis||DOPS|
|Analyse the results of gene fusion testing by FISH||DOPS|
|Analyse the results of microsatellite analysis for monitoring bone marrrow transplantation||DOPS|
|Analyse results generated by Next Generation Sequencing||DOPS|
|Use bioinformatic tools to interpret the clinical significance of a sequence variant||DOPS|
|Prepare a clinical report for a patient referred with an aquired cancer||DOPS|
|Assess microsatellite results from a colorectal cancer sample for a mismatch repair defect||DOPS|
|Participate in an MDT meeting with other healthcare professionals||OCE|
|Take a patient history can be undertaken in virtual patient environment||OCE|
|Discuss patient results with a healthcare professional telephone or in person||OCE|
The academic parts of this module will be detailed and communicated to you by your university. Please contact them if you have questions regarding this module and its assessments. The module titles in your MSc may not be exactly identical to the work-based modules shown in the e-portfolio. Your modules will be aligned, however, to ensure that your academic and work-based learning are complimentary.