Aim of this module
This module provides trainees with an introduction into the molecular mechanisms leading to the development of solid cancer and the associated genomic testing. Using colorectal cancer and melanoma as exemplars throughout, they will understand the organisation and delivery of a diagnostic tumour genotyping service. They will perform some common methods used for diagnostic testing of these cancers and gain an understanding into both the analysis and interpretation of patient results, and the need for additional investigations and the importance of cross-discipline working in both the laboratory and wider clinical setting.
|Number||Work-based learning outcome||Title||Knowledge|
Receive samples and referral information for a range of colorectal cancer and melanoma referrals
Perform histopathological sample preparation and morphological assessment of neoplastic cells
Select and perform the correct genetic tests(s) for samples from patients referred with colorectal cancer
Select and perform the correct genetic tests(s) for samples from patients referred with melanoma
Use bioinformatics software and associated databases for analysis and interpretation of genomic aberrations in colorectal and melanoma cancer
Prepare a range of full and accurate interpretative clinical reports for patients referred with colorectal cancer and melanoma.
Assist with the preparation of cases to be discussed and reviewed in an MDT meeting with other healthcare professionals
|You must complete|
|2 Case-based discussion(s)|
|2 of the following DOPS / OCEs|
|Perform basic morphological assessment demonstrating awareness of neoplastic cells, cellularity, necrosis and tumour material||DOPS|
|Perform DNA extraction of suitable samples types which may include but are not limited to FFPE, fresh tumour and blood||DOPS|
|Perform tumour genotype analysis using bioinformatic pipelines and associated tools||DOPS|
|Produce a diagnostic clinical report for a patient with hotspot mutation(s)||DOPS|
|Discuss patient results with a healthcare professional telephone or in person||OCE|
|Discuss implications of receiving an unlabeled sample with a healthcare professional.||OCE|
|Participate in an MDT meeting with other healthcare professionals||OCE|
|Prepare a clinical report||DOPS|
The academic parts of this module will be detailed and communicated to you by your university. Please contact them if you have questions regarding this module and its assessments. The module titles in your MSc may not be exactly identical to the work-based modules shown in the e-portfolio. Your modules will be aligned, however, to ensure that your academic and work-based learning are complimentary.