Aim of this module
This module provides trainees with a detailed understanding of the molecular mechanisms of lung and ovarian cancer and the associated genomic testing. With these exemplars trainees will develop an understanding of the organisation and delivery of a complex cancer genotyping service. They will perform common laboratory methods, interpret genomic results and develop an understanding of the need for additional investigations as well as use of associated targeted therapies. Trainees will build upon previous knowledge gained in the context of relapse, metastasis, resistance, as well as the roles of first and second line therapeutics. Furthermore, this module will increase the knowledge base for applications to monitor disease and use less-invasive sampling strategies. They will consider how this impacts on patient management, personalised medicine and therapeutic options. They will also develop an awareness of common central nervous system (CNS) tumours. Trainees will understand the contribution of germline mutations to cancer and the implications for patients and their families. They will recognize the importance of cross-discipline cancer genomic analysis.
Using lung and ovarian cancer;
|Number||Work-based learning outcome||Title||Knowledge|
Select the correct genomic tests for a range of lung and ovarian cancer referrals and sample types
Perform morphological identification of tumour material for lung and/or ovarian cancer.
Perform and interpret genomic testing to identify single nucleotide variation for patients referred with lung cancer
Perform molecular investigations for identifying fusion gene translocations which may impact patient management.
Use appropriate bioinformatics analysis of genotyping results.
Perform analyses and interpret genomic results from non-invasive liquid biopsy samples
Prepare a range of diagnostic clinical reports for a lung cancer patient.
Produce a diagnostic report for an ovarian cancer patient which should include germline mutation and appropriate additional information.
Observe a clinic where a patient is being given results of laboratory tests that include genetic analysis. Reflect on this experience and present to colleagues
Assist with the preparation of cases to be discussed and reviewed in an MDT meeting with other healthcare professionals
|You must complete|
|3 Case-based discussion(s)|
|3 of the following DOPS / OCEs|
|Perform morphological assessment on lung and ovarian tissue, demonstrating awareness of cellularity, necrosis and tumour material.||DOPS|
|Perform DNA extraction of suitable samples types other than FFPE material, such as fresh tumour and liquid biopsies.||DOPS|
|Describe and perform technologies suitable for tumour genotyping and identifying fusion gene translocations.||DOPS|
|Perform tumour genotyping analysis using bioinformatics pipelines and associated tools.||DOPS|
|Produce a diagnostic clinical report for a patient with familial ovarian cancer.||DOPS|
|Prepare a draft report for an inappropriate referral received.||DOPS|
|Participate in an MDT meeting with other healthcare professionals||OCE|
|Discuss patient results with a healthcare professional telephone or in person||OCE|
|Discuss implications of receiving an unlabeled sample with a healthcare professional.||OCE|
|Discuss an inappropriate referral with a healthcare professional||OCE|
The academic parts of this module will be detailed and communicated to you by your university. Please contact them if you have questions regarding this module and its assessments. The module titles in your MSc may not be exactly identical to the work-based modules shown in the e-portfolio. Your modules will be aligned, however, to ensure that your academic and work-based learning are complimentary.
Using lung and ovarian cancer;